RUBCN

Across TCGA patient cohorts, RUBCN mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUBCN-associated genes across cancer lineages are RAD51, PCNA, and AMPK_pT172. Each is linked with RUBCN in more than 2 cancer types. Because this analysis shows association rather than direction, both RUBCN-to-partner and partner-to-RUBCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by RUBCN-low versus RUBCN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUBCN→partner) and Y-score (partner→RUBCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAD51 →	+0.218	+2.178	.003	.035	2	3
UCEC	PCNA →	+0.144	+1.502	.026	.027	3	2
UCEC	AMPK_pT172 →	+0.272	+3.584	.028	.002	3	2
UCEC	Chk2_pT68 →	-0.140	-2.492	.012	.001	3	2
UCEC	Cyclin-B1 →	+0.557	+1.999	<.001	.008	3	2
COAD	TFRC →	+0.601	+3.347	.016	.005	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

RAD51 by RUBCN expression — COAD

Explore this box plot interactively →