RTL8C

Across TCGA pan-cancer cohorts, RTL8C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RTL8C data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RTL8C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RTL8C expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where RTL8C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.586	0.917	.004	29	view →
LUAD	OS	Quartile	II,III,IV	0.220	0.837	.031	6	view →
CCRCC	DFS	Tertile	All	0.573	0.817	.035	4	view →
HNSC	OS	Median	All	0.795	0.608	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RTL8C–LSCC (DFS)

Open the LSCC breakdown →