RTL8C

Across TCGA pan-cancer cohorts, RTL8C RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RTL8C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RTL8C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RTL8C is over-expressed in tumor, although a few such as UCEC and BLCA show the opposite, repressed pattern.

KIRP, HNSC, and UCEC are the cancer types where RTL8C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RTL8C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	+1.107	<.001	8	view →
HNSC	Female	II,III,IV	+0.796	<.001	8	view →
UCEC	All	III,IV	−0.751	<.001	8	view →
BLCA	All	All	−0.627	.005	8	view →
LIHC	Female	All	+1.432	<.001	6	view →
CHOL	All	All	+2.620	<.001	5	view →
BRCA	All	All	−0.298	<.001	4	view →
THCA	All	All	+0.168	.004	3	view →
READ	Female	All	−1.442	.005	2	view →
ESCA	All	II,III,IV	−0.609	.049	2	view →
PRAD	All	All	−0.478	<.001	2	view →
COAD	Female	II,III,IV	−0.652	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RTL8C–KIRP

Open the KIRP breakdown →