RTL8C

Across TCGA patient cohorts, RTL8C mutation is significantly associated with the RNA expression of many other genes, with 395 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTL8C-associated genes across cancer lineages are SELPLG, MIR6499, and PRSS53. Each is linked with RTL8C in more than 1 cancer types. Because this analysis shows association rather than direction, both RTL8C-to-partner and partner-to-RTL8C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SELPLG grouped by RTL8C-low versus RTL8C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTL8C→partner) and Y-score (partner→RTL8C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SELPLG →	+0.714	+2.807	.006	.003	3	2
BRCA	MIR6499 →	+0.357	+4.739	<.001	.005	3	1
UCEC	PRSS53 →	+0.255	+3.400	.008	.004	3	1
UCEC	TEX30 →	+0.707	+3.330	.001	.005	3	1
UCEC	WAS →	+0.681	+3.370	.003	.005	3	1
UCEC	TEX29 →	+0.566	+3.467	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 395 associations by consensus.

SELPLG by RTL8C expression — UCEC

Explore this box plot interactively →