RTL3

Across TCGA pan-cancer cohorts, RTL3 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated RTL3 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher RTL3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RTL3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

THYM, ESCA, and UCEC are the cancer types where RTL3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
ESCA	OS	Median	II,III,IV	0.313	0.717	<.001	18	view →
UCEC	DFS	Median	All	0.944	0.626	.007	14	view →
BLCA	DFS	Median	All	0.193	0.521	.026	12	view →
SCLC	DFS	Median	II,III,IV	0.137	0.562	.013	12	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	9	view →
COAD	DFS	Median	All	1.000	0.774	.022	6	view →
LUSC	OS	Median	All	1.000	0.379	.011	4	view →
SKCM	DFS	Median	IV	1.000	0.125	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

RTL3–THYM (OS)

Open the THYM breakdown →