RTL3

Across TCGA pan-cancer cohorts, RTL3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RTL3’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where RTL3 RNA is repressed in tumor relative to normal tissue. In most cancer types RTL3 is over-expressed in tumor, although a few such as UCEC and BLCA show the opposite, repressed pattern.

UCEC, BLCA, and COAD are the cancer types where RTL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RTL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	−0.836	<.001	6	view →
BLCA	Male	III,IV	−0.362	.023	6	view →
COAD	All	II,III,IV	−0.141	<.001	6	view →
HNSC	All	All	+0.082	.009	6	view →
KICH	Male	All	−0.061	<.001	5	view →
BRCA	All	II,III,IV	−0.264	<.001	4	view →
STAD	Female	All	−0.657	.034	3	view →
LUSC	All	All	−0.166	<.001	3	view →
LUAD	All	All	−0.135	<.001	3	view →
KIRC	Male	All	+0.031	.019	2	view →
LIHC	All	All	+0.010	.033	2	view →
THCA	All	All	−0.034	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RTL3–UCEC

Open the UCEC breakdown →