RTL3

Across TCGA patient cohorts, RTL3 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTL3-associated genes across cancer lineages are ATM, INPP4B, and Caspase-7-cleavedD198. Each is linked with RTL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both RTL3-to-partner and partner-to-RTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RTL3-low versus RTL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTL3→partner) and Y-score (partner→RTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.559	-1.807	<.001	<.001	3	4
UCEC	INPP4B →	-0.202	-1.171	.036	.022	3	3
UCEC	Caspase-7-cleavedD198 →	+0.504	+2.107	.004	.002	3	3
SKCM	CDK1 →	+0.173	+3.459	.012	.005	3	3
LUAD	MYH11 →	-0.893	-2.000	.019	.031	3	2
UCEC	14-3-3_beta →	-0.072	-1.558	.016	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

ATM by RTL3 expression — UCEC

Explore this box plot interactively →