RTL3

Across TCGA cell cohorts, RTL3 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RTL3-associated genes across cancer lineages are IL2, PBOV1, and CBY1. Each is linked with RTL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTL3-to-partner and partner-to-RTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL2 grouped by RTL3-low versus RTL3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTL3→partner) and Y-score (partner→RTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IL2 →	+0.053	+5.149	<.001	<.001	3	1
LUNG_NSCLC_LUAD	PBOV1 →	+0.028	+3.760	<.001	.008	3	1
LARGE_INTESTINE	CBY1 →	+0.606	+3.137	.004	.007	3	1
LARGE_INTESTINE	ACER1 →	+0.064	+2.823	.007	.002	3	1
LARGE_INTESTINE	OR4F21 →	+0.140	+2.556	<.001	.006	3	1
LARGE_INTESTINE	FAM153B →	+0.415	+3.011	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

IL2 by RTL3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →