RTF2

Across TCGA cell cohorts, RTF2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RTF2-associated genes across cancer lineages are PRSS54, C14orf180, and MCHR2. Each is linked with RTF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTF2-to-partner and partner-to-RTF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by RTF2-low versus RTF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTF2→partner) and Y-score (partner→RTF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRSS54 →	+0.046	+3.930	<.001	.003	3	1
LARGE_INTESTINE	C14orf180 →	+0.126	+4.155	<.001	.003	3	1
BLOOD_Leukemia	MCHR2 →	+0.046	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR9K2 →	+0.012	+5.539	.007	.003	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.117	+5.539	<.001	.003	3	1
BLOOD_Leukemia	ARSH →	+0.012	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PRSS54 by RTF2 expression — LARGE_INTESTINE

Explore this box plot interactively →