RSRP1

Across TCGA patient cohorts, RSRP1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSRP1-associated genes across cancer lineages are p62 Lck ligand, BRD4, and 4E-BP1. Each is linked with RSRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSRP1-to-partner and partner-to-RSRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by RSRP1-low versus RSRP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSRP1→partner) and Y-score (partner→RSRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.609	+3.321	<.001	.010	3	1
UCEC	BRD4 →	+0.336	+2.177	.016	.035	3	1
UCEC	4E-BP1 →	+0.489	+2.837	<.001	.035	3	1
UCEC	Shc_pY317 →	-0.247	-3.321	.001	.010	2	1
UCEC	MEK1 →	+0.496	+3.321	.009	.010	1	1
UCEC	Src_pY527 →	-0.469	-3.321	.037	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by RSRP1 expression — UCEC

Explore this box plot interactively →