RSPO4

Across TCGA patient cohorts, RSPO4 mutation is significantly associated with the RNA expression of many other genes, with 263 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPO4-associated genes across cancer lineages are ACTG1P2, FAM238B, and B3GNTL1P2. Each is linked with RSPO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPO4-to-partner and partner-to-RSPO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTG1P2 grouped by RSPO4-low versus RSPO4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO4→partner) and Y-score (partner→RSPO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ACTG1P2 →	+0.071	+3.407	<.001	.003	3	2
COAD	FAM238B →	+0.546	+3.025	.003	.009	3	2
COAD	B3GNTL1P2 →	+0.098	+4.225	<.001	.007	3	2
UCEC	RNU6-1228P →	+0.179	+3.879	.004	.009	3	2
UCEC	AKR1B1P2 →	+0.268	+3.245	<.001	.001	3	2
UCEC	TOMM22P5 →	+0.360	+2.745	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 263 associations by consensus.

ACTG1P2 by RSPO4 expression — COAD

Explore this box plot interactively →