RSPO3

Across TCGA patient cohorts, RSPO3 protein abundance is significantly associated with the RNA expression of many other genes, with 644 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPO3-associated genes across cancer lineages are TIMP3, TRIM9, and PLCB4. Each is linked with RSPO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPO3-to-partner and partner-to-RSPO3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RSPO3 versus TIMP3 in UCEC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO3→partner) and Y-score (partner→RSPO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMP3 →	+1.789	+0.914	.002	.006	3	1
UCEC	TRIM9 →	+0.698	+0.969	<.001	<.001	3	1
UCEC	PLCB4 →	-1.026	-1.038	.001	.001	3	1
UCEC	MYL9 →	+1.151	+0.854	<.001	.001	3	1
UCEC	CHRDL1 →	+1.930	+0.976	.003	.003	3	1
UCEC	SRPX →	+1.310	+0.976	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 644 associations by consensus.

RSPO3 vs TIMP3 — UCEC

Explore this scatter interactively →