RSPO3

Across TCGA patient cohorts, RSPO3 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPO3-associated genes across cancer lineages are ASNS, c-Met_pY1235, and 4E-BP1. Each is linked with RSPO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPO3-to-partner and partner-to-RSPO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by RSPO3-low versus RSPO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO3→partner) and Y-score (partner→RSPO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.383	+1.874	.003	.049	3	2
UCEC	c-Met_pY1235 →	+0.058	+1.584	.029	.019	3	2
UCEC	4E-BP1 →	+0.311	+2.145	.001	.009	3	2
UCEC	Di-Ras3 →	-0.115	-3.308	.031	.009	3	2
UCEC	eIF4E →	+0.173	+2.700	.022	.006	3	1
UCEC	ACC1 →	+0.362	+3.183	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ASNS by RSPO3 expression — UCEC

Explore this box plot interactively →