RSPO3

Across TCGA cell cohorts, RSPO3 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible RSPO3-associated genes across cancer lineages are CFHR2, MTRNR2L10, and SLC5A8. Each is linked with RSPO3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RSPO3-to-partner and partner-to-RSPO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by RSPO3-low versus RSPO3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO3→partner) and Y-score (partner→RSPO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	3
BLOOD_Leukemia	MTRNR2L10 →	+0.028	+4.922	<.001	.009	3	2
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	MAGEB4 →	+0.026	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	RNASE11 →	+0.099	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	OR56A1 →	+0.059	+4.736	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

CFHR2 by RSPO3 expression — BLOOD_Leukemia

Explore this box plot interactively →