RSPO2

Across TCGA patient cohorts, RSPO2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPO2-associated genes across cancer lineages are Notch1, ATM, and C-Raf_pS338. Each is linked with RSPO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RSPO2-to-partner and partner-to-RSPO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by RSPO2-low versus RSPO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO2→partner) and Y-score (partner→RSPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.144	+1.594	.004	.042	3	3
UCEC	ATM →	-0.582	-3.906	<.001	<.001	3	3
LUSC	C-Raf_pS338 →	-0.123	-2.990	.026	.036	3	2
UCEC	A-Raf_pS299 →	-0.105	-2.115	.014	.017	3	2
UCEC	JNK_pT183_Y185 →	-0.155	-2.000	.010	.030	3	2
UCEC	MEK1 →	+0.528	+4.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Notch1 by RSPO2 expression — UCEC

Explore this box plot interactively →