RSPO2

Across TCGA pan-cancer cohorts, RSPO2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RSPO2 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RSPO2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RSPO2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LIHC show a favorable association.

KIRC, ACC, and BLCA are the cancer types where RSPO2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.820	0.898	.005	83	view →
ACC	OS	Median	All	0.772	0.958	<.001	53	view →
BLCA	DFS	Median	All	0.266	0.455	.001	39	view →
READ	DFS	Tertile	II,III,IV	0.622	0.984	.007	30	view →
SKCM	DFS	Quartile	All	0.316	0.167	<.001	27	view →
LIHC	DFS	Median	All	0.527	0.329	.005	25	view →
THYM	DFS	Median	II,III,IV	0.753	0.925	.009	24	view →
LAML	DFS	Median	All	0.453	0.680	<.001	24	view →
MESO	OS	Quartile	All	0.290	0.561	.009	22	view →
LUAD	DFS	Quartile	All	0.758	0.612	.004	19	view →
STAD	DFS	Median	IV	0.644	0.288	.004	17	view →
BRCA	OS	Quartile	II,III,IV	0.858	0.924	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RSPO2–KIRC (DFS)

Open the KIRC breakdown →