RSPO2

Across TCGA cell cohorts, RSPO2 RNA expression is significantly associated with the go_rna of many other GO terms, with 398 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RSPO2-associated GO terms across cancer lineages are Negative regulation of stem cell population maintenance, Regulation of DNA damage checkpoint, and Regulation of protein neddylation. Each is linked with RSPO2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RSPO2-to-partner and partner-to-RSPO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of stem cell population maintenance grouped by RSPO2-low versus RSPO2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO2→partner) and Y-score (partner→RSPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of stem cell population maintenance →	+0.045	+1.225	.007	.002	3	3
SOFT_TISSUE	Regulation of DNA damage checkpoint →	+0.054	+1.189	.007	.003	3	3
CNS	Regulation of protein neddylation →	+0.058	+0.504	.001	.001	3	3
SOFT_TISSUE	Protein neddylation →	+0.059	+0.930	.004	.001	2	4
SOFT_TISSUE	Regulation of nuclear division →	+0.058	+0.771	.008	.008	3	3
SOFT_TISSUE	Nucleosome disassembly →	+0.071	+0.792	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 398 associations by consensus.

Negative regulation of stem cell population maintenance by RSPO2 expression — SOFT_TISSUE

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