RSPO2

Across TCGA cell cohorts, RSPO2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RSPO2-associated genes across cancer lineages are OXT, C5orf52, and ELOA3DP. Each is linked with RSPO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPO2-to-partner and partner-to-RSPO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by RSPO2-low versus RSPO2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO2→partner) and Y-score (partner→RSPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OXT →	+0.070	+4.977	<.001	.007	3	1
SKIN	C5orf52 →	+0.062	+5.415	<.001	.004	3	1
LARGE_INTESTINE	ELOA3DP →	+0.031	+4.273	<.001	.006	3	1
OVARY	CDRT15L2 →	+0.022	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OXT by RSPO2 expression — SKIN

Explore this box plot interactively →