RSPH4A

Across TCGA pan-cancer cohorts, RSPH4A mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated RSPH4A data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RSPH4A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RSPH4A expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LUAD and GBM are the cancer types where RSPH4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.612	0.987	.014	11	view →
GBM	DFS	Quartile	All	0.589	0.338	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

RSPH4A–LUAD (OS)

Open the LUAD breakdown →