RSPH4A

Across TCGA pan-cancer cohorts, RSPH4A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RSPH4A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RSPH4A RNA is repressed in tumor relative to normal tissue. In most cancer types RSPH4A is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LUAD are the cancer types where RSPH4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RSPH4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−1.640	<.001	11	view →
KIRC	Male	III,IV	−0.807	<.001	11	view →
LUAD	All	III,IV	−1.942	<.001	9	view →
THCA	Male	III,IV	−1.144	<.001	9	view →
LUSC	Female	II,III,IV	−2.542	<.001	8	view →
PRAD	All	All	+0.347	<.001	2	view →
CHOL	All	All	+0.282	.035	1	view →
BLCA	All	IV	−0.194	.046	1	view →
STAD	All	All	+0.178	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RSPH4A–KICH

Open the KICH breakdown →