RSPH4A

Across TCGA patient cohorts, RSPH4A mutation is significantly associated with the RNA expression of many other genes, with 4,538 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPH4A-associated genes across cancer lineages are PPP3CC, MIR4305, and FAM177A1. Each is linked with RSPH4A in more than 2 cancer types. Because this analysis shows association rather than direction, both RSPH4A-to-partner and partner-to-RSPH4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP3CC grouped by RSPH4A-low versus RSPH4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPH4A→partner) and Y-score (partner→RSPH4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP3CC →	+0.730	+2.545	<.001	<.001	3	3
SKCM	MIR4305 →	+0.257	+3.699	<.001	.003	3	2
UCEC	FAM177A1 →	+0.400	+2.534	<.001	<.001	3	2
UCEC	ATP5F1A →	+0.513	+2.534	<.001	<.001	3	2
UCEC	FRRS1 →	+0.695	+3.098	<.001	<.001	3	2
UCEC	NTAN1 →	+0.564	+3.053	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,538 associations by consensus.

PPP3CC by RSPH4A expression — UCEC

Explore this box plot interactively →