RSPH4A

Across TCGA patient cohorts, RSPH4A mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPH4A-associated genes across cancer lineages are Notch1, ASNS, and Caspase-7-cleavedD198. Each is linked with RSPH4A in more than 2 cancer types. Because this analysis shows association rather than direction, both RSPH4A-to-partner and partner-to-RSPH4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by RSPH4A-low versus RSPH4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPH4A→partner) and Y-score (partner→RSPH4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.181	+2.392	<.001	<.001	3	3
UCEC	ASNS →	+0.395	+1.362	.001	.037	3	3
UCEC	Caspase-7-cleavedD198 →	+0.448	+1.720	.032	.025	3	2
UCEC	4E-BP1 →	+0.311	+2.837	.001	.001	3	2
UCEC	Gab2 →	+0.308	+2.000	.014	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.147	-1.874	.013	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Notch1 by RSPH4A expression — UCEC

Explore this box plot interactively →