RSPH4A

Across TCGA cell cohorts, RSPH4A mutation is significantly associated with the mutation status of many other genes, with 5,977 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RSPH4A-associated genes across cancer lineages are MKI67, CUL7, and CCDC40. Each is linked with RSPH4A in more than 3 cancer types. Because this analysis shows association rather than direction, both RSPH4A-to-partner and partner-to-RSPH4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MKI67 grouped by RSPH4A-low versus RSPH4A-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPH4A→partner) and Y-score (partner→RSPH4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MKI67 →	+4.437	+5.000	.007	.007	1	4
OVARY	CUL7 →	+4.977	+4.415	.007	.007	1	4
LUNG_NSCLC_LUAD	CCDC40 →	+5.000	+4.187	.008	.008	1	4
LUNG_NSCLC_LUAD	ATP10B →	+4.000	+5.266	<.001	<.001	1	4
LUNG_NSCLC_LUAD	LRRC4B →	+4.584	+4.584	<.001	<.001	1	4
LUNG_NSCLC_LUAD	PPFIA2 →	+2.540	+4.222	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,977 associations by consensus.

MKI67 by RSPH4A expression — BONE

Explore this box plot interactively →