RSPH14

Across TCGA patient cohorts, RSPH14 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPH14-associated genes across cancer lineages are A-Raf_pS299, mTOR_pS2448, and VHL. Each is linked with RSPH14 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPH14-to-partner and partner-to-RSPH14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by RSPH14-low versus RSPH14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPH14→partner) and Y-score (partner→RSPH14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.135	-3.000	.009	.036	3	2
UCEC	mTOR_pS2448 →	-0.140	-3.302	.031	.010	3	2
UCEC	VHL →	-0.641	-2.459	.030	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.180	-2.999	.014	.035	3	1
UCEC	MEK1 →	+0.344	+2.115	.031	.019	3	1
UCEC	Notch1 →	+0.188	+2.115	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

A-Raf_pS299 by RSPH14 expression — UCEC

Explore this box plot interactively →