RSPH14

Across TCGA pan-cancer cohorts, RSPH14 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RSPH14 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher RSPH14 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RSPH14 expression acts as an unfavorable survival marker, although some lineages such as KIRP and READ show a favorable association.

KIRP, READ, and LGG are the cancer types where RSPH14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.795	0.570	<.001	121	view →
READ	DFS	Quartile	All	0.904	0.471	<.001	63	view →
LGG	DFS	Tertile	All	0.376	0.551	<.001	48	view →
UVM	DFS	Tertile	II,III,IV	0.280	0.790	<.001	44	view →
LIHC	DFS	Median	All	0.475	0.603	.002	34	view →
SARC	DFS	Median	All	0.696	0.520	<.001	27	view →
MESO	DFS	Quartile	All	0.390	0.221	.017	24	view →
ACC	OS	Median	IV	0.308	0.733	.006	23	view →
STAD	DFS	Median	IV	0.155	0.565	.009	18	view →
PCPG	OS	Median	All	1.000	0.775	.016	12	view →
LUSC	OS	Median	II,III,IV	0.658	0.324	.007	10	view →
KIRC	DFS	Quartile	All	0.729	0.537	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RSPH14–KIRP (OS)

Open the KIRP breakdown →