RSPH1

Across TCGA patient cohorts, RSPH1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPH1-associated genes across cancer lineages are TFRC, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with RSPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPH1-to-partner and partner-to-RSPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by RSPH1-low versus RSPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPH1→partner) and Y-score (partner→RSPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.694	+2.584	.005	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.651	+3.189	.018	.010	3	2
UCEC	EGFR_pY1068 →	-0.407	-3.700	<.001	.001	3	1
UCEC	FASN →	+0.380	+3.000	.038	.036	3	1
UCEC	Gab2 →	+0.562	+2.999	<.001	.035	3	1
UCEC	ACC1 →	+0.399	+2.820	.018	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

TFRC by RSPH1 expression — UCEC

Explore this box plot interactively →