RSPH1

Across TCGA pan-cancer cohorts, RSPH1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RSPH1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RSPH1 RNA is repressed in tumor relative to normal tissue. In most cancer types RSPH1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and STAD are the cancer types where RSPH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RSPH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−3.113	<.001	11	view →
KIRC	All	II,III,IV	−0.882	<.001	11	view →
STAD	Male	III,IV	+1.276	<.001	10	view →
THCA	Male	IV	−1.470	<.001	9	view →
LUSC	Female	II,III,IV	−2.847	<.001	8	view →
LUAD	Female	All	−1.672	<.001	8	view →
BRCA	All	III,IV	+1.231	<.001	6	view →
CHOL	Male	All	+2.138	<.001	5	view →
LIHC	All	All	+0.328	.001	5	view →
ESCA	All	II,III,IV	+2.820	.020	2	view →
PRAD	All	All	+0.553	<.001	2	view →
COAD	All	II,III,IV	+0.392	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RSPH1–KICH

Open the KICH breakdown →