RSPH1

Across TCGA cell cohorts, RSPH1 mutation is significantly associated with the mutation status of many other genes, with 999 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RSPH1-associated genes across cancer lineages are PLD2, POLR2B, and ZNF318. Each is linked with RSPH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RSPH1-to-partner and partner-to-RSPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLD2 grouped by RSPH1-low versus RSPH1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPH1→partner) and Y-score (partner→RSPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PLD2 →	+5.014	+5.584	.003	.003	1	3
LUNG_NSCLC_LUAD	POLR2B →	+4.187	+5.000	.008	.008	1	3
BLOOD_Lymphoma	ZNF318 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	CLSTN1 →	+6.014	+6.014	.001	.001	1	3
LARGE_INTESTINE	CSPP1 →	+2.865	+4.217	.007	.007	1	2
LARGE_INTESTINE	UNC5B →	+2.865	+4.217	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 999 associations by consensus.

PLD2 by RSPH1 expression — BLOOD_Lymphoma

Explore this box plot interactively →