RSL1D1

Across TCGA pan-cancer cohorts, RSL1D1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RSL1D1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RSL1D1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RSL1D1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where RSL1D1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.636	0.899	.005	59	view →
CCRCC	DFS	Tertile	All	0.537	0.883	<.001	54	view →
LSCC	DFS	Tertile	II,III,IV	0.917	0.538	.002	29	view →
PDAC	DFS	Quartile	II,III,IV	0.265	0.564	.004	21	view →
UCEC	DFS	Tertile	III,IV	1.000	0.383	.020	8	view →
LUAD	DFS	Quartile	All	0.625	1.000	.019	5	view →
GBM	OS	Quartile	All	0.689	0.202	.002	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RSL1D1–HNSC (DFS)

Open the HNSC breakdown →