RSL1D1

Across TCGA pan-cancer cohorts, RSL1D1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RSL1D1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RSL1D1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RSL1D1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where RSL1D1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RSL1D1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.970	<.001	12	view →
KIRP	All	II,III,IV	+0.943	<.001	11	view →
COAD	Male	All	+1.101	<.001	9	view →
LIHC	Male	II,III,IV	+1.054	<.001	9	view →
HNSC	Male	IV	+0.645	<.001	9	view →
LUAD	All	III,IV	+0.589	<.001	9	view →
STAD	All	II,III,IV	+0.792	<.001	7	view →
CHOL	Male	All	+2.081	<.001	5	view →
READ	All	All	+0.870	<.001	5	view →
LUSC	Male	All	+0.692	<.001	5	view →
KICH	Female	All	−0.843	.001	3	view →
UCEC	All	All	−0.510	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RSL1D1–KIRC

Open the KIRC breakdown →