RSKR

Across TCGA pan-cancer cohorts, RSKR Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RSKR data layer compared with 25 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher RSKR Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RSKR expression acts as an unfavorable survival marker.

KICH, SCLC, and KIRC are the cancer types where RSKR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.035	0.904	<.001	30	view →
SCLC	OS	Median	II,III,IV	0.192	0.699	.002	18	view →
KIRC	OS	Median	II,III,IV	0.172	0.696	.030	12	view →
LGG	OS	Median	All	0.243	0.830	.001	12	view →
BRCA	OS	Median	All	0.410	0.924	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RSKR–KICH (DFS)

Open the KICH breakdown →