RSKR

Across TCGA pan-cancer cohorts, RSKR RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RSKR’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RSKR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RSKR is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

BLCA, HNSC, and KICH are the cancer types where RSKR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RSKR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+1.139	<.001	10	view →
HNSC	All	III,IV	+0.335	<.001	10	view →
KICH	Female	II,III,IV	−0.990	<.001	9	view →
COAD	All	All	+0.396	<.001	7	view →
LIHC	Male	All	+0.250	<.001	7	view →
UCEC	All	All	+0.465	.009	6	view →
LUSC	All	All	+0.554	<.001	5	view →
KIRC	All	All	−0.267	.002	5	view →
CHOL	All	All	+1.344	<.001	4	view →
STAD	All	II,III,IV	+0.621	<.001	4	view →
READ	All	All	+0.575	.007	2	view →
LUAD	Female	All	+0.558	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RSKR–BLCA

Open the BLCA breakdown →