RSKR

Across TCGA patient cohorts, RSKR mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSKR-associated genes across cancer lineages are Bax, A-Raf_pS299, and IGFBP2. Each is linked with RSKR in more than 1 cancer types. Because this analysis shows association rather than direction, both RSKR-to-partner and partner-to-RSKR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by RSKR-low versus RSKR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSKR→partner) and Y-score (partner→RSKR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.257	+2.321	.033	.035	3	2
UCEC	A-Raf_pS299 →	-0.190	-2.321	.001	.035	3	1
UCEC	IGFBP2 →	-0.719	-2.321	.027	.035	3	1
UCEC	MSH2 →	-0.274	-3.459	.018	.005	3	1
UCEC	Myosin-IIa →	+0.229	+2.818	.013	.035	3	1
UCEC	p62 Lck ligand →	+0.581	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Bax by RSKR expression — UCEC

Explore this box plot interactively →