RS1

Across TCGA patient cohorts, RS1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RS1-associated genes across cancer lineages are A-Raf_pS299, Ku80, and Notch1. Each is linked with RS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RS1-to-partner and partner-to-RS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by RS1-low versus RS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RS1→partner) and Y-score (partner→RS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.127	-2.115	.014	.019	3	1
UCEC	Ku80 →	+0.314	+2.128	.002	.010	3	1
UCEC	Notch1 →	+0.139	+2.115	.023	.019	3	1
UCEC	p62 Lck ligand →	+0.316	+2.807	.026	.003	3	1
UCEC	Annexin-1 →	+0.725	+3.169	.001	.018	3	1
UCEC	S6_pS240_S244 →	+0.405	+3.000	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

A-Raf_pS299 by RS1 expression — UCEC

Explore this box plot interactively →