RS1

Across TCGA cell cohorts, RS1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RS1-associated genes across cancer lineages are GML, SLC35G3, and NKX2-6. Each is linked with RS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RS1-to-partner and partner-to-RS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by RS1-low versus RS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RS1→partner) and Y-score (partner→RS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.080	+4.152	<.001	.009	3	1
BLOOD_Leukemia	SLC35G3 →	+0.036	+4.874	.001	.002	3	1
BLOOD_Leukemia	NKX2-6 →	+0.489	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	OR1G1 →	+0.083	+4.705	<.001	.003	3	1
BLOOD_Leukemia	DEFB108B →	+0.161	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	GUCA2A →	+0.039	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GML by RS1 expression — BLOOD_Leukemia

Explore this box plot interactively →