RRS1

Across TCGA patient cohorts, RRS1 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. COAD shows the largest number of these associations.

The most reproducible RRS1-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and B-cells. Each is linked with RRS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRS1-to-partner and partner-to-RRS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by RRS1-low versus RRS1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRS1→partner) and Y-score (partner→RRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD8+ T-cells →	+0.059	+5.142	<.001	.041	3	1
COAD	CD8+ Tcm →	+0.101	+4.917	<.001	.048	3	1
COAD	B-cells →	+0.094	+4.408	<.001	.020	3	1
COAD	CD4+ naive T-cells →	+0.031	+5.142	<.001	.041	3	1
UCEC	Melanocytes →	-0.012	-3.268	.026	.011	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CD8+ T-cells by RRS1 expression — COAD

Explore this box plot interactively →