RRS1

Across TCGA pan-cancer cohorts, RRS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RRS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RRS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RRS1 is over-expressed in tumor.

COAD, HNSC, and KIRC are the cancer types where RRS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RRS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+2.017	<.001	12	view →
HNSC	Male	IV	+1.191	<.001	12	view →
KIRC	All	All	+0.422	<.001	11	view →
STAD	Male	II,III,IV	+1.787	<.001	9	view →
KIRP	Male	III,IV	+1.190	<.001	9	view →
LUAD	All	III,IV	+1.113	<.001	9	view →
THCA	Male	All	+0.480	<.001	9	view →
LIHC	Male	II,III,IV	+2.397	<.001	8	view →
LUSC	Male	III,IV	+1.910	<.001	7	view →
BRCA	All	III,IV	+0.763	<.001	6	view →
CHOL	Male	All	+2.753	<.001	5	view →
READ	All	All	+1.003	.004	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RRS1–COAD

Open the COAD breakdown →