RRS1

Across TCGA cell cohorts, RRS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,729 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RRS1-associated GO terms across cancer lineages are Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Maturation of SSU-rRNA, and Ribosome biogenesis. Each is linked with RRS1 in more than 17 cancer types. Because this analysis shows association rather than direction, both RRS1-to-partner and partner-to-RRS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by RRS1-low versus RRS1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RRS1→partner) and Y-score (partner→RRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.122	+0.868	<.001	<.001	3	18
LUNG_SCLC	Maturation of SSU-rRNA →	+0.157	+0.976	<.001	<.001	3	17
LUNG_SCLC	Ribosome biogenesis →	+0.117	+0.826	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Nucleolar large rRNA transcription by RNA polymerase I →	+0.138	+0.785	.001	.009	3	17
BONE	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.141	+1.001	.002	<.001	3	17
BONE	Maturation of 5.8S rRNA →	+0.133	+0.920	<.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,729 associations by consensus.

Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by RRS1 expression — BONE

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