RRS1-AS1

Across TCGA pan-cancer cohorts, RRS1-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated RRS1-AS1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher RRS1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RRS1-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and BRCA show a favorable association.

LUSC, BRCA, and DLBC are the cancer types where RRS1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	All	0.479	0.351	.004	47	view →
BRCA	OS	Median	IV	0.813	0.318	.002	38	view →
DLBC	DFS	Quartile	IV	0.128	1.000	.017	26	view →
UVM	OS	Median	All	0.406	0.890	.002	26	view →
KIRC	DFS	Tertile	All	0.866	0.711	.004	23	view →
READ	OS	Quartile	II,III,IV	0.821	0.405	.001	22	view →
BLCA	OS	Quartile	II,III,IV	0.770	0.665	.020	12	view →
STAD	DFS	Median	IV	0.670	0.173	.007	12	view →
MESO	DFS	Median	II,III,IV	0.301	0.599	.018	12	view →
PCPG	DFS	Median	All	0.677	0.932	.010	8	view →
CHOL	OS	Tertile	III,IV	0.290	0.855	.027	6	view →
LUAD	OS	Median	All	0.753	0.646	.033	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

RRS1-AS1–LUSC (DFS)

Open the LUSC breakdown →