RRS1-AS1

Across TCGA pan-cancer cohorts, RRS1-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RRS1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RRS1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types RRS1-AS1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and COAD are the cancer types where RRS1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RRS1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.509	<.001	12	view →
THCA	All	IV	−0.189	<.001	11	view →
COAD	All	IV	−0.154	<.001	11	view →
KICH	All	II,III,IV	−0.468	<.001	9	view →
READ	All	All	−0.117	<.001	5	view →
BLCA	All	III,IV	+0.077	.035	5	view →
KIRP	Male	All	−0.254	<.001	4	view →
LUSC	Female	II,III,IV	−0.060	.009	3	view →
PRAD	All	All	+0.172	.011	2	view →
CHOL	All	All	−0.111	.004	2	view →
LUAD	Female	II,III,IV	−0.051	.021	2	view →
ESCA	All	All	−0.327	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RRS1-AS1–KIRC

Open the KIRC breakdown →