RRP9

Across TCGA patient cohorts, RRP9 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRP9-associated genes across cancer lineages are EGFR_pY1068, ERK2, and MEK1. Each is linked with RRP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRP9-to-partner and partner-to-RRP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RRP9-low versus RRP9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP9→partner) and Y-score (partner→RRP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.225	-2.115	.040	.019	3	1
UCEC	ERK2 →	+0.226	+2.115	.007	.019	3	1
UCEC	MEK1 →	+0.329	+2.115	.039	.019	3	1
UCEC	p70-S6K →	+0.181	+2.142	.031	.010	3	1
UCEC	PDCD4 →	-0.570	-3.321	.005	.009	3	1
UCEC	PDK1_pS241 →	+0.200	+2.321	.007	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by RRP9 expression — UCEC

Explore this box plot interactively →