RRP8

Across TCGA patient cohorts, RRP8 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRP8-associated genes across cancer lineages are MEK1, A-Raf_pS299, and Ku80. Each is linked with RRP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRP8-to-partner and partner-to-RRP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RRP8-low versus RRP8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP8→partner) and Y-score (partner→RRP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.464	+2.415	<.001	.003	3	2
UCEC	A-Raf_pS299 →	-0.173	-2.459	<.001	.019	3	1
UCEC	Ku80 →	+0.280	+2.100	.001	.003	3	1
UCEC	mTOR_pS2448 →	-0.122	-2.095	.032	.017	3	1
UCEC	Myosin-IIa →	+0.226	+2.329	.003	.003	3	1
UCEC	p62 Lck ligand →	+0.391	+3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MEK1 by RRP8 expression — UCEC

Explore this box plot interactively →