RRP8

Across TCGA pan-cancer cohorts, RRP8 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated RRP8 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RRP8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RRP8 expression acts as an unfavorable survival marker, although some lineages such as THYM and CHOL show a favorable association.

ACC, LIHC, and KICH are the cancer types where RRP8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.261	0.622	<.001	98	view →
LIHC	OS	Median	All	0.593	0.773	<.001	88	view →
KICH	DFS	Tertile	III,IV	0.221	1.000	.002	83	view →
KIRC	DFS	Median	IV	0.225	0.483	.003	32	view →
LGG	DFS	Median	All	0.778	0.879	<.001	27	view →
MESO	DFS	Quartile	III,IV	0.254	0.548	.004	24	view →
LUSC	OS	Median	III,IV	0.435	0.681	.005	24	view →
PCPG	DFS	Quartile	All	0.450	0.969	.001	21	view →
THYM	DFS	Median	All	0.899	0.417	.001	18	view →
CHOL	DFS	Quartile	All	0.797	0.093	.010	16	view →
READ	DFS	Median	IV	0.179	0.936	.010	9	view →
HNSC	OS	Median	II,III,IV	0.628	0.786	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

RRP8–ACC (DFS)

Open the ACC breakdown →