RRP8

Across TCGA cell cohorts, RRP8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,788 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RRP8-associated GO terms across cancer lineages are Nucleolus organization, Nucleolar chromatin organization, and rDNA heterochromatin formation. Each is linked with RRP8 in more than 17 cancer types. Because this analysis shows association rather than direction, both RRP8-to-partner and partner-to-RRP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleolus organization grouped by RRP8-low versus RRP8-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP8→partner) and Y-score (partner→RRP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Nucleolus organization →	+0.094	+0.785	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Nucleolar chromatin organization →	+0.108	+0.694	.004	.002	3	16
LIVER	rDNA heterochromatin formation →	+0.120	+0.801	.008	.004	3	14
URINARY_TRACT	Telomere tethering at nuclear periphery →	+0.143	+0.697	.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Transcription by RNA polymerase I →	+0.087	+0.678	.009	.003	3	9
BLOOD_Leukemia	DNA-templated transcription initiation →	+0.044	+0.358	<.001	.007	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,788 associations by consensus.

Nucleolus organization by RRP8 expression — LUNG_SCLC

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