RRP36

Across TCGA patient cohorts, RRP36 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRP36-associated genes across cancer lineages are eIF4E, FoxM1, and JNK2. Each is linked with RRP36 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRP36-to-partner and partner-to-RRP36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RRP36-low versus RRP36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP36→partner) and Y-score (partner→RRP36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.247	+3.807	.009	<.001	3	1
UCEC	FoxM1 →	+0.318	+2.000	.006	.032	3	1
UCEC	JNK2 →	+0.322	+2.348	<.001	.018	3	1
UCEC	Ku80 →	+0.348	+3.472	.001	.002	3	1
UCEC	Notch1 →	+0.137	+2.820	.030	.035	3	1
UCEC	PKC-delta_pS664 →	-0.128	-3.160	.018	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eIF4E by RRP36 expression — UCEC

Explore this box plot interactively →