RRP36

Across TCGA pan-cancer cohorts, RRP36 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RRP36’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RRP36 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RRP36 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LUAD, and BLCA are the cancer types where RRP36 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RRP36 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.754	<.001	12	view →
LUAD	Female	III,IV	+0.775	<.001	11	view →
BLCA	All	III,IV	+0.512	<.001	10	view →
LIHC	Female	II,III,IV	+1.415	<.001	9	view →
STAD	Male	II,III,IV	+1.004	<.001	9	view →
KICH	Female	II,III,IV	−1.265	<.001	8	view →
LUSC	Female	II,III,IV	+0.778	<.001	8	view →
COAD	Female	II,III,IV	+0.551	<.001	8	view →
UCEC	All	II,III,IV	+0.789	<.001	6	view →
BRCA	All	III,IV	+0.624	<.001	6	view →
CHOL	Male	All	+2.293	<.001	5	view →
THCA	Male	III,IV	−0.407	.003	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RRP36–HNSC

Open the HNSC breakdown →