RRP1B

Across TCGA cell cohorts, RRP1B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,055 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RRP1B-associated GO terms across cancer lineages are Ribosome biogenesis, DNA replication initiation, and rRNA metabolic process. Each is linked with RRP1B in more than 19 cancer types. Because this analysis shows association rather than direction, both RRP1B-to-partner and partner-to-RRP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosome biogenesis grouped by RRP1B-low versus RRP1B-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP1B→partner) and Y-score (partner→RRP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Ribosome biogenesis →	+0.117	+0.833	<.001	.001	3	19
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.187	+1.135	.003	.003	2	20
LUNG_SCLC	rRNA metabolic process →	+0.122	+0.694	<.001	.006	3	18
OVARY	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.142	+1.118	<.001	<.001	3	18
BLOOD_Myeloma	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.172	+1.257	<.001	.001	3	18
BREAST	Nuclear pore complex assembly →	+0.152	+0.774	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,055 associations by consensus.

Ribosome biogenesis by RRP1B expression — LUNG_SCLC

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