RRP1B

Across TCGA pan-cancer cohorts, RRP1B RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated RRP1B data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher RRP1B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RRP1B expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

MESO, KIRP, and ACC are the cancer types where RRP1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.251	0.515	<.001	111	view →
KIRP	OS	Median	All	0.571	0.800	<.001	99	view →
ACC	DFS	Median	All	0.386	0.772	<.001	77	view →
UCS	DFS	Median	II,III,IV	0.553	0.136	<.001	60	view →
CESC	DFS	Quartile	All	0.695	0.875	<.001	54	view →
LIHC	DFS	Tertile	All	0.402	0.663	<.001	51	view →
LGG	OS	Median	All	0.378	0.538	<.001	44	view →
THCA	OS	Median	All	0.899	0.984	.003	29	view →
COAD	DFS	Quartile	III,IV	0.247	0.772	.005	27	view →
LUSC	OS	Median	IV	0.255	0.851	.021	24	view →
UCEC	DFS	Tertile	All	0.661	0.788	.002	24	view →
KIRC	DFS	Quartile	III,IV	0.540	0.798	.004	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

RRP1B–MESO (OS)

Open the MESO breakdown →