RRP1B

Across TCGA cell cohorts, RRP1B mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RRP1B-associated genes across cancer lineages are SPINK9, CCL25, and CLEC10A. Each is linked with RRP1B in more than 1 cancer types. Because this analysis shows association rather than direction, both RRP1B-to-partner and partner-to-RRP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by RRP1B-low versus RRP1B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP1B→partner) and Y-score (partner→RRP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPINK9 →	+0.048	+4.415	<.001	.007	3	2
SKIN	CCL25 →	+0.052	+4.095	.006	.009	3	1
SKIN	CLEC10A →	+0.041	+4.273	<.001	.006	3	1
SKIN	TMEM210 →	+0.036	+4.415	<.001	.007	3	1
SKIN	CCL14 →	+0.144	+4.095	<.001	.009	3	1
BLOOD_Lymphoma	PLA2G2E →	+0.032	+5.169	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

SPINK9 by RRP1B expression — SKIN

Explore this box plot interactively →