RRP1B

Across TCGA cell cohorts, RRP1B mutation is significantly associated with the mutation status of many other genes, with 2,750 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RRP1B-associated genes across cancer lineages are MYLK, PIK3CG, and USP42. Each is linked with RRP1B in more than 3 cancer types. Because this analysis shows association rather than direction, both RRP1B-to-partner and partner-to-RRP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYLK grouped by RRP1B-low versus RRP1B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP1B→partner) and Y-score (partner→RRP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MYLK →	+3.847	+5.108	.001	.001	1	4
BLOOD_Leukemia	PIK3CG →	+3.623	+4.665	<.001	<.001	1	3
LARGE_INTESTINE	USP42 →	+1.874	+3.700	.005	.005	1	3
LARGE_INTESTINE	PIK3C2A →	+2.459	+4.247	.001	.001	1	3
BLOOD_Leukemia	NKTR →	+3.430	+3.313	.005	.005	1	3
BLOOD_Leukemia	INO80D →	+3.360	+3.946	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,750 associations by consensus.

MYLK by RRP1B expression — BLOOD_Lymphoma

Explore this box plot interactively →